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禽流行性感冒H7N9病毒能在人类呼吸道上皮细胞进

作者:admin  日期:2018-11-08 14:34  人气:
高致病性禽流感是禽流行性感冒的简称。是由A型禽流行性感冒病毒引起的一种禽类(家禽和野禽)传染病。世界动物卫生组织(OIE)将其列为必须报告的动物传染病,我国将其列为一类动物疫病。而H7N9型禽流感则是一种新型禽流感,于2013年3月底在上海和安徽两地率先发现。
 
Highly pathogenic avian influenza is the abbreviation of avian influenza. It is a kind of avian (poultry and wild bird) infectious disease caused by the A avian influenza virus. The World Organization for Animal Health (OIE) classifies it as an animal infectious disease that must be reported, and China classifies it as a class of animal epidemics. H7N9 avian influenza, a new type of avian influenza, was first detected in Shanghai and Anhui at the end of March 2013.
 
 
 
高致病性禽流感,禽流行性感冒,H7N9型禽流感
 
Highly pathogenic avian influenza, avian influenza, H7N9 avian influenza
 
 
 
近日,一个项新的研究表明,高致病性H7N9病毒能通过呼吸飞沫在雪貂之间传播,并引起致命感染。
 
Recently, a new study has shown that highly pathogenic H7N9 virus can spread among ferrets through respiratory droplets and cause fatal infection.
 
 
 
近日一个跨国研究团队在《细胞—宿主和微生物》期刊上发文称,高致病性(HPAI)H7N9病毒在人类气道细胞和动物模型的肺中能有效复制,并通过呼吸飞沫在雪貂之间传播,而且对常用的抗病毒药物反应极低。
 
A multinational team recently published in the Journal Cell-Host and Microbiology that the highly pathogenic (HPAI) H7N9 virus can replicate effectively in the lungs of human airway cells and animal models, spread among ferrets through breathing droplets, and respond very little to commonly used antiviral drugs.
 
 
 
在这项研究中,中国疾控中心病毒病预防控制所舒跃龙团队及日本和美国合作者,研究了高致病性H7N9病毒在人体的复制能力、致病性和传播能力,并与先前描述的低致病性H7N9病毒进行了比较,以评估其大流行潜力。
 
In this study, the replication, pathogenicity and transmission of highly pathogenic H7N9 virus in humans were studied by Shu Yuelong team of China CDC Institute for Viral Disease Prevention and Control and Japanese and American collaborators, and compared with the previously described low pathogenic H7N9 virus in order to assess its pandemic potential.
 
 
 
结果显示,高致病性H7N9病毒在人类呼吸道上皮细胞和小鼠、雪貂及非人灵长类动物中都能有效复制。与低致病性H7N9病毒相比,高致病性H7N9病毒在小鼠和雪貂中也更致病。而且,所研究的高致病性病毒在雪貂的大脑中表现出更强的复制力,并引起致命感染。此外,所有测试的病毒均能通过呼吸飞沫在雪貂之间传播。
 
The results showed that highly pathogenic H7N9 virus could replicate effectively in human respiratory epithelial cells and mice, ferrets and non-human primates. Compared with the low pathogenic H7N9 virus, highly pathogenic H7N9 virus is also more pathogenic in mice and ferrets. Moreover, the highly pathogenic viruses studied in this study showed stronger reproducibility in the mink's brain and caused fatal infections. In addition, all tested viruses can spread through ferrets through respiratory droplets.
 
 
 
由于抗病毒药物目前是治疗和预防H7N9人类感染病例的唯一选择,该团队评估了抗流感药物的效力,发现在动物模型中神经氨酸苷酶抑制剂的有效性是有限的。
 
Since antivirals are currently the only option for the treatment and prevention of H7N9 human infections, the team assessed the effectiveness of antivirals and found that the effectiveness of neuraminidase inhibitors in animal models is limited.

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